SENESCENCE
نویسندگان
چکیده
منابع مشابه
Is There any Mean to Postpone The Menopausal Ovarian Senescence?
The ovarian reserve (OR) gradually decreases throughout the female fertile life. This continuous depletion in OR is irreversible. This occurs through a programmed cell death known apoptosis. Some factors hasten such depletion such as chemo- and radiotherapy. Others have been investigated in trials to preserve the OR including gonadotropins, cytokines, growth hormones, nitric oxide and reorganiz...
متن کاملMicromanaging senescence
Normal somatic cells have a limited capacity for division in culture and eventually enter a state of terminal growth arrest termed replicative senescence [1]. Cells that fail to undergo senescence divide indefinitely and develop chromosomal aberrations resulting in neoplastic transformation. Senescence is believed to be a tumor suppressor mechanism that ensures that cells permanently exit the c...
متن کاملComplete senescence
ISSN: 1538-4101 (Print) 1551-4005 (Online) Journal homepage: http://www.tandfonline.com/loi/kccy20 Complete senescence: RB and PML share the task Mathieu Vernier & Gerardo Ferbeyre To cite this article: Mathieu Vernier & Gerardo Ferbeyre (2014) Complete senescence: RB and PML share the task, Cell Cycle, 13:5, 696-696, DOI: 10.4161/cc.28090 To link to this article: http://dx.doi.org/10.4161/cc.2...
متن کاملNegligible Senescence
In the development of a “new evolutionary genetics of aging” there is one issue that, in my opinion, requires additional attention: negligible senescence. Trees with longevities of hundreds of years or small invertebrates, like the hydra, that appear immortal seem to defy traditional theories of aging. Can we imagine a scenario in which Hamiltonian forces of natural selection never decline? Can...
متن کاملNevus Senescence
Melanomas and nevi share many of the same growth-promoting mutations. However, melanomas grow relentlessly while benign nevi eventually undergo growth arrest and stabilize. The difference in their long-term growth potential may be attributed to activation of cellular senescence pathways. The primary mediator of senescence in nevi appears to be p16. Redundant, secondary senescence systems are al...
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ژورنال
عنوان ژورنال: BMJ
سال: 1932
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.3742.583